AOD-9604 Growth Hormone Fragment Research
AOD-9604 research — Anti-Obesity Drug Fragment 176-191 of human growth hormone, lipolytic mechanisms, adipose tissue metabolism, fat oxidation, cartilage repair, and GRAS safety data.
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In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Anti-Obesity Drug Fragment 9604
Also known as: AOD-9604, hGH Fragment 176-191, Tyr-hGH177-191
AOD-9604 is a modified fragment of human growth hormone (hGH) spanning amino acids 176-191, with an added tyrosine at the N-terminus to enhance stability. It was developed to isolate the lipolytic (fat-burning) activity of growth hormone from its growth-promoting and diabetogenic effects. The peptide stimulates lipolysis and inhibits lipogenesis through a mechanism distinct from the GH receptor, a...
Quick Facts
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-...
MW: 1817.12 g/mol
CAS: 221231-10-3
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C and used within 21 days. Protect...
Latest Research Articles
Deep-dive articles from the System Peptides Research Network.
What Is AOD-9604? Growth Hormone Fragment Research
Research review of AOD-9604 — the hGH fragment 176-191 studied for lipolytic activity without IGF-1 elevation or glucose...
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Evidence-based ranking of metabolic research peptides in 2026. AOD-9604, GLP-2 TZ, GLP-3 RT, 5-Amino-1MQ, SLU-PP-332, an...
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Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Weight Loss & Fat Metabolism
Known as a 'fat-burning peptide,' this modified fragment of human growth hormone stimulates metabolism and specifically targets stubborn fat without affecting blood sugar or causing cell growth.
Insulin Sensitivity
A peptide fragment of human growth hormone designed specifically for fat loss and metabolic regulation without directly impacting blood sugar levels in research models.
Lean Mass & Body Composition
AOD-9604 targets peripheral fat metabolism through lipolysis stimulation and lipogenesis inhibition — without appetite suppression or GH receptor binding — for clean body composition research.
Cartilage Repair
Beyond fat metabolism, AOD-9604 has shown promising results in cartilage repair research and received FDA GRAS (Generally Recognized as Safe) status in 2014.
Frequently Asked Questions
Common questions about aod-9604 research research, purity standards, and sourcing.
What is AOD-9604?
AOD-9604 is a modified fragment (amino acids 176-191) of human growth hormone with a tyrosine addition at the N-terminus. It retains the lipolytic (fat-burning) activity of hGH while lacking its growth-promoting and diabetogenic effects. It received FDA GRAS status in 2014.
How does AOD-9604 promote fat metabolism?
AOD-9604 stimulates beta-3 adrenergic receptor-mediated lipolysis in adipose tissue and inhibits lipogenic enzymes (fatty acid synthase, acetyl-CoA carboxylase). It does not bind the GH receptor, does not increase IGF-1, and does not affect insulin sensitivity or glucose tolerance.
What makes AOD-9604 different from full growth hormone?
AOD-9604 isolates the lipolytic domain of hGH without its growth-promoting effects. This means no IGF-1 elevation, no insulin resistance, no cellular proliferation risk — only peripheral fat metabolism effects. It also has FDA GRAS status, indicating a favorable safety profile.
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